Reveals the locations of Secret Rooms and Super Secret Rooms for the current and all future floors. Health Up, Tears Up, and Shot Speed Down. After 6 hits, you will stop gaining Damage upgrades. For items such as Technology and Brimstone, the upgrades are applied normally.ĭamage Up for the rest of the floor when the player takes damage. Unlocked by using the Blood Donation machine 30 times.ĭamage Up and Range Up, however, only to one of the player's tears. Can be dropped from Blood Donation machines. Unlocked by donating 150 pennies to the Shop. Gives the player 1 black heart and grants immunity to floor curses. Slows down all other orbitals, but does not take up any of the three slots you have for orbitals, allowing for a total of 4.Ĭauses the player to fart poison gas when they take damage, poisoning nearby enemies.Įvil Up. Spawns a very large orbital that blocks shots and deals contact damage. It flies very quickly around the player in contrast to the other fly orbitals.Īll of the player's familiars become much bigger, making them deal more damage. Spawns a white fly orbital when the player takes damage. It respawns after exploding shortly after. The player can take damage if the familiar explodes next to them. Spawns a large familiar black fly that explodes on contact with enemies. Spacebar items can be overcharged, allowing them to be charged twice instead of once. Tears also have a chance to slow enemies and their projectiles. Leaves a trail of tar behind the player that slows enemies and projectiles. A third will transform the orbital into a familiar that will attack nearby enemies by dealing contact damage. A second will cause the orbital to shoot tears in the direction the player shoots, with a chance to charm enemies. Spawns an orbital that can evolve, similarly to the Cube Of Meat item.
Allows the player to deal contact damage when running into enemies. Leaves a trail of tears behind the player that deals damage to enemies. They will fire off in the direction that you orginally shot them in. Holding down the button that shoots tears will cause shots to float in the same place until you release the button. Bue Baby secret unlocks can be unlocked using this item. Upon death, the player respawns as Blue Baby with 3 soul hearts. If the player takes damage, they will leave a trail of blood behind him that damages enemies.
Unlocked by beating the Dark Room with Cain. Spawns a familiar that mirrors the player's movements and shoots in the opposite direction. Unlocked by beating The Chest with Azazel. Tears now have the chance to induce the fear effect, causing enemies to run away from the player for a short period of time. Removes all red heart containers and gives you 6 black hearts. The player shoots two tears instead of just one.Īll spacebar item total charges are reduced by 1. Unlocked by beating the Boss Rush Room with Blue Baby. Spawns a familiar fly that can be moved around using arrow keys, similarly to the Ludovico Technique. Some items do very little things for the player, while others can practically win you the game by just having them. Most are always active, but there are items that activate when something happens, such as if you get hit. There are a lot of permanent items in The Binding of Isaac: Rebirth, that all have lots of really cool and interesting effects.
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